Menin-MLL Inhibitor

カタログ番号	製品名	別名	ターゲット
T9399	Menin-MLL inhibitor 20		Epigenetic Reader Domain , Histone Methyltransferase
	Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities.		Epigenetic Reader Domain , Histone Methyltransferase
T2649	Menin-MLL inhibitor MI-2	Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
	Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
T2643	MI-3	Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3	Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
	MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).
T12002	Menin-MLL inhibitor 4		Others
	Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .		Others
T79737	Menin-MLL inhibitor 29		Epigenetic Reader Domain
	Menin-MLL Inhibitor 29 (Compound C1) is a Menin-MLL protein-protein interaction (PPI) inhibitor that demonstrates high affinity to Menin with a dissociation constant (K D) of 138 nM and impedes Menin's interaction with M...		Epigenetic Reader Domain
T12943	SNDX-5613		Epigenetic Reader Domain , Histone Methyltransferase
	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.		Epigenetic Reader Domain , Histone Methyltransferase
T13336	VTP50469		Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
	VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
T72360	Menin-MLL inhibitor 26
	Menin-MLL inhibitor 26 is a Menin-MLL inhibitor. Menin-MLL inhibitor 26 also is an active reference. Menin-MLL inhibitor 26 can inhibits cell growth. Menin-MLL inhibitor 26 can be used for the research of leukemia .
T79117	Menin-MLL inhibitor 27		Epigenetic Reader Domain
	Menin-MLL inhibitor 27 effectively inhibits the interaction between Menin and MLL, serving as a potential tool in cancer research, particularly for acute myeloid leukemia (AML) [1].		Epigenetic Reader Domain
T78151	Bleximenib oxalate	Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain
	Menin-MLL Inhibitor 24 (compound A) oxalate, a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, is utilized in cancer research [1].		Epigenetic Reader Domain
T72135	(1s,4s)-Menin-MLL inhibitor-23
	(1s,4s)-Menin-MLL Inhibitor-23, an enantiomer of Menin-MLL Inhibitor-23 (Example 99A), functions as an inhibitor of the menin-MLL interaction [1].
T28036	MI-2-2	MI22,MI 2 2	Histone Methyltransferase
	MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.		Histone Methyltransferase
T69628	Iptacopan hydrochloride hydrate
	Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor.
TQ0069	MI-503		Epigenetic Reader Domain , Histone Methyltransferase
	MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.		Epigenetic Reader Domain , Histone Methyltransferase
T11925	M‑89		Epigenetic Reader Domain , Histone Methyltransferase
	M-89, a highly potent and specific inhibitor of the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction, exhibits a Kd of 1.4 nM for menin binding. This compound holds potential for treating MLL leukemia...		Epigenetic Reader Domain , Histone Methyltransferase
T16072	MI-538		Epigenetic Reader Domain , Histone Methyltransferase
	MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).		Epigenetic Reader Domain , Histone Methyltransferase
TQ0058	MI-463		Epigenetic Reader Domain , Histone Methyltransferase
	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).		Epigenetic Reader Domain , Histone Methyltransferase
T22978	MI-2 (hydrochloride)		Others
	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).		Others
T24484	ML399	VU-0516340,VU 0516340,ML-399,VU0516340,ML 399
	ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action.
T15831	M-525		Others
	M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, ir...		Others
T13336L	VTP50469 fumarate		Others
	VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.		Others
T24472	MIV-6R	MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R
	MIV-6R is an inhibitor of the menin- MLL interaction that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanisms of action.
T27134	DCYM21	DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21
	DCYM21 is an inhibitor of menin-MLL interaction. DCYM21 demonstrates potent and selective blockage of proliferation and induces both cell cycle arrest and differentiation of leukemia cells harboring MLL translocations.
T39938	M-1211
	M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
T69629	M‑89 MLL inhibitor
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular men...
T39585	Ziftomenib	KO-539	Histone Methyltransferase
	Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.		Histone Methyltransferase
T24463	MI-1481	MI 1481
	MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo i...
T39937	M-808
	M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM.